184 research outputs found
Adapting to climate risks and extreme weather: guide for mining - minerals industry professionals
AbstractExtreme weather events in Australia over recent years have highlighted the costs for Australian mining and mineral processing operations of being under-prepared for adapting to climate risk. For example, the 2010/2011 Queensland floods closed or restricted production of about forty out of Queenslandâs fifty coal mines costing more than $2 billion in lost production.Whilst mining and mineral professionals have experience with risk management and managing workplace health and safety, changes to patterns of extreme weather events and future climate impacts are unpredictable. Responding to these challenges requires planning and preparation for events that many people have never experienced before. With increasing investor and public concern for the impact of such events, this guide is aimed at assisting a wide range of mining and mineral industry professionals to incorporate planning and management of extreme weather events and impacts from climate change into pre-development, development and construction, mining and processing operations and post-mining phases. The guide should be read in conjunction with the research final report which describes the research process for developing the guide and reflects on challenges and lessons for adaptation research from the project.The Institute for Sustainable Futures, University of Technology Sydney (UTS) led the development of the guide with input from the Centre for Mined Land Rehabilitation, University of Queensland and a Steering Committee from the Australasian Institute of Mining and Metallurgyâs Sustainability Committee and individual AusIMM members, who volunteered their time and experience. As the situation of every mining and mineral production operation is going to be different, this guide has been designed to provide general information about the nature of extreme weather events, and some specific examples of how unexpectedly severe flooding, storm, drought, high temperature and bushfire events have affected mining and mineral processing operations. A number of case studies used throughout the guide also illustrate the ways forward thinking operations have tackled dramatically changing climatic conditions.Each section of the guide outlines a range of direct and indirect impacts from a different type of extreme weather, and provides a starting point for identifying potential risks and adaptation options that can be applied in different situations. The impacts and adaptation sections provide guidance on putting the key steps into practice by detailing specific case examples of leading practice and how a risk management approach can be linked to adaptive planning. More information about specific aspects of extreme weather, planning and preparation for the risks presented by these events, and tools for undertaking climate related adaptation is provided in the âAdditional Resourcesâ section
Measurement of the cosmic ray spectrum above eV using inclined events detected with the Pierre Auger Observatory
A measurement of the cosmic-ray spectrum for energies exceeding
eV is presented, which is based on the analysis of showers
with zenith angles greater than detected with the Pierre Auger
Observatory between 1 January 2004 and 31 December 2013. The measured spectrum
confirms a flux suppression at the highest energies. Above
eV, the "ankle", the flux can be described by a power law with
index followed by
a smooth suppression region. For the energy () at which the
spectral flux has fallen to one-half of its extrapolated value in the absence
of suppression, we find
eV.Comment: Replaced with published version. Added journal reference and DO
Energy Estimation of Cosmic Rays with the Engineering Radio Array of the Pierre Auger Observatory
The Auger Engineering Radio Array (AERA) is part of the Pierre Auger
Observatory and is used to detect the radio emission of cosmic-ray air showers.
These observations are compared to the data of the surface detector stations of
the Observatory, which provide well-calibrated information on the cosmic-ray
energies and arrival directions. The response of the radio stations in the 30
to 80 MHz regime has been thoroughly calibrated to enable the reconstruction of
the incoming electric field. For the latter, the energy deposit per area is
determined from the radio pulses at each observer position and is interpolated
using a two-dimensional function that takes into account signal asymmetries due
to interference between the geomagnetic and charge-excess emission components.
The spatial integral over the signal distribution gives a direct measurement of
the energy transferred from the primary cosmic ray into radio emission in the
AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air
shower arriving perpendicularly to the geomagnetic field. This radiation energy
-- corrected for geometrical effects -- is used as a cosmic-ray energy
estimator. Performing an absolute energy calibration against the
surface-detector information, we observe that this radio-energy estimator
scales quadratically with the cosmic-ray energy as expected for coherent
emission. We find an energy resolution of the radio reconstruction of 22% for
the data set and 17% for a high-quality subset containing only events with at
least five radio stations with signal.Comment: Replaced with published version. Added journal reference and DO
Measurement of the Radiation Energy in the Radio Signal of Extensive Air Showers as a Universal Estimator of Cosmic-Ray Energy
We measure the energy emitted by extensive air showers in the form of radio
emission in the frequency range from 30 to 80 MHz. Exploiting the accurate
energy scale of the Pierre Auger Observatory, we obtain a radiation energy of
15.8 \pm 0.7 (stat) \pm 6.7 (sys) MeV for cosmic rays with an energy of 1 EeV
arriving perpendicularly to a geomagnetic field of 0.24 G, scaling
quadratically with the cosmic-ray energy. A comparison with predictions from
state-of-the-art first-principle calculations shows agreement with our
measurement. The radiation energy provides direct access to the calorimetric
energy in the electromagnetic cascade of extensive air showers. Comparison with
our result thus allows the direct calibration of any cosmic-ray radio detector
against the well-established energy scale of the Pierre Auger Observatory.Comment: Replaced with published version. Added journal reference and DOI.
Supplemental material in the ancillary file
Prophylactic Cefazolin Dosing and Surgical Site Infections: Does the Dose Matter in Obese Patients?
Background
Most surgical prophylaxis guidelines recommend a 3-g cefazolin intravenous dose in patients weighing â„â120 kg. However, this recommendation is primarily based on pharmacokinetic studies rather than robust clinical evidence. This study aimed to compare the prevalence of surgical site infections (SSIs) in obese and non-obese patients (body mass index â„â30 kg/m2 and <â30 kg/m2), and those weighing â„â120 kg and <â120 kg, who received 2- g cefazolin preoperatively.
Methods
A retrospective case-control study was conducted in adult elective surgical patients. Patients receiving 2- g cefazolin were grouped as obese and non-obese, and by weight (â„â120 kg or <â120 kg). The 90-day prevalence of SSI and potential contributing factors were investigated.
Results
We identified 152 obese (median 134 kg) and 152 non-obese control (median 73 kg) patients. Baseline characteristics were similar between groups, except for an increased prevalence in the obese group of diabetes (35.5% vs 13.2%; pâ<â0.001) and an American Society of Anaesthesiologists Score of 3 (61.8% vs 17.1%; pâ<â0.001). While not statistically significant, the prevalence of SSI in the obese group was almost double that in the non-obese group (8.6% vs 4.6%; pâ=â0.25) and in patients weighing â„â120 kg (nâ=â102) compared to those weighing <â120 kg (nâ=â202) (9.8% vs 5.0%; pâ=â0.17).
Conclusion
The prevalence of SSI was not significantly increased in obese patients, or those weighing â„â120 kg, who received cefazolin 2- g prophylactically; however, trends toward an increase were evident. Large-scale randomised trials are needed to examine whether a 2-g or 3-g cefazolin is adequate to prevent SSI in obese (and â„â120 kg) individuals
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20 : G protein- coupled receptors
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.14748. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2019, and supersedes data presented in the 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.Peer reviewe
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